1 Epidemiology of Muscle Mass Loss with Age 1 Marjolein Visser
2 Definitions of Sarcopenia 8 John E. Morley and Alfonso J. Cruz-Jentoft
3 Muscle Biology and mTORC1 Signaling in Aging 20 Blake B. Rasmussen and Elena Volpi
4 The Role of the Nervous System in Muscle Atrophy 41 Minal Bhanushali, Robin Conwit, Jeffrey Metter and LuigiFerrucci
5 Nutrition, Protein Turnover and Muscle Mass 59 Stephane Walrand, Christelle Guillet and Yves Boirie
6 The Complex Relation between Muscle Mass and Muscle Strength74 Todd M. Manini, David W. Russ and Brian C. Clark
7 Is Sarcopenia a Geriatric Syndrome? 104 Jean-Pierre Michel and Alfonso J. Cruz-Jentoft
8 Adverse Outcomes and Functional Consequences of Sarcopenia114 David R. Thomas
9 A Lifecourse Approach to Sarcopenia 125 Avan Aihie Sayer
10 Cachexia and Sarcopenia 141 Maurizio Muscaritoli, Simone Lucia and Filippo RossiFanelli
11 Sarcopenia and Frailty 154 Cornel C. Sieber
12 Sarcopenia, Osteoporosis and Fractures 168 Tommy Cederholm
13 Sarcopenic Obesity 181 Mauro Zamboni, Andrea P. Rossi and Elena Zoico
14 Imaging of Skeletal Muscle 193 Thomas F. Lang
15 Measurements of Muscle Mass, Equations and Cut-off Points205 Marjolein Visser and Laura Schaap
16 Measurement of Muscle Strength and Power 226 Michael Drey and Jurgen M. Bauer
17 Measurements of Physical Performance 238 Rolland Yves, Gabor Abellan van Kan and Matteo Cesari
18 Exercise Interventions to Improve Sarcopenia 252 Mark D. Peterson and Jos´e A. Serra-Rexach
19 Nutritional Approaches to Treating Sarcopenia 275 Douglas Paddon-Jones and Luc van Loon
20 The Future of Drug Treatments 296 Francesco Landi, Yves Rolland and Graziano Onder
21 Sarcopenia: Is It Preventable? 324 Maurits Vandewoude and Ivan Bautmans
Index 339
Sarcopenia is a major therapeutic challenge and a public healthpriority in both the US and Europe. More than two decades after theword was first used to define a distinct clinical condition, thedefinition of sarcopenia remains open for discussion,nd itsclinical relevance is still not fully understood. This bookprovides some answers. It is a valuable addition to theexisting literature, providing a one-stop shop for state-of-the-artinformation on a topic of particular relevance for geriatriciansand all those who care for the older population.
Sarcopenia has serious health consequences of sarcopenia interms of frailty, disability, morbidity, and mortality. Identifyinghigh risk groups of older people is straightforward, but making adiagnosis is more difficult. Having addressed the definition ofsarcopenia the book therefore goes on to discuss current openquestions that concern the clinical management of thecondition. Chapters cover nosology, pathophysiology, clinicalidentification, and treatment: for example, is sarcopenia a normalpart of the ageing process? When does it become a disease state? Isit only a morphologic or functional abnormality, or is it anage-related disease? Epidemiological, clinical, diagnosticand therapeutic aspects of sarcopenia are covered, as well aspossible methods of prevention and treatment options. Defines and explains the clinical relevance of sarcopenia Covers all recent scientific evidence Discusses treatment options Considers ways of prevention
Written by experts in the field from both the US and Europe,this book will be of practical interest to geriatricians,clinicians and professionals working in nursing homes, nutritionand sport medicine. It is also a valuable and comprehensivereference work for professionals, post-graduates and researchers onage-related diseases, disability, nutrition and geriatricmedicine.
Dr. Alfonso J. Cruz Jentoft is a specialist in GeriatricMedicine and Gerontology. He currently leads the GeriatricDepartment of the Hospital Universitario Ramón y Cajal and ofthe Clínica Ruber, both in Madrid, Spain. He is Past Presidentof the European Union Geriatric Medicine Society (EUGMS) and is nowmember of its Academic Board. He has also served as Secretary andBoard Member of the Sociedad Española de Geriatría yGerontología. He represents Spain in the Council of theInternational Association of Geriatrics and Gerontology(IAGG). Dr. Cruz-Jentoft is associate editor of the journal EuropeanGeriatric Medicine, and member of the editorial board of otherleading geriatric European journals. He is author of La vidaempieza a los cincuenta (Life starts at fifty, Temas de Hoy) and Lavejez positiva (Positive ageing, Esfera de los libros), and editoror co-author of many medical textbooks and more than 100peer-reviewed articles. His present areas of active researchinclude sarcopenia and nutrition in older people, geriatricpharmacotherapy, Alzheimer's disease and geriatricassessment.
Dr. John E. Morley, known internationally as agerontological researcher, clinician, and educator, became theDirector of the Division of Geriatric Medicine and the DammertProfessor of Gerontology. In addition to extensive personalscientific achievements, Dr. Morley has directed the clinicaltraining programs in both endocrinology and geriatrics andsupervised research activities ranging from basic biomedicalinvestigation to epidemiology and health services research. He isthe editor of the Journal of Gerontology: Medical Sciences,and recipient of the Ipsen Foundation of Longevity Award in 2001,the American Geriatrics Society's Lascher/Manning Award forLifetime Achievement in Geriatrics in 2002, and the GerontologicalSociety of America's Freeman Award in 2004. He has developed anumber of educational games and has a special interest incontinuous quality improvement (CQI).
"Sarcopenia is defined as loss of muscle mass. Althoughaddressed to gerontologists, the book is of interest topediatricians and psychiatrists treating anorexia and chronicdiseases." (Pediatric Endocrinology Reviews, 1September 2014)
"This book contains a substantial and recent bibliography,and it will provide stimulating reading for both clinicians andresearch workers who are seeking ways of enhancing physicalfunction in the elderly." (Applied Physiology,Nutrition & Metabolism, 1 October 2012)
