This book constitutes thoroughly refereed and revised selected papers from the proceedings of 19th European Conference on Multi-Agent Systems, EUMAS 2022, held in Dusseldorf, Germany, during September 14-16, 2022.The 23 full papers included in this book were carefully reviewed and selected from 36 submissions. The book also contains 6 short summaries of talks from PhD students at the PhD day. The papers deal with current topics in the research and development of multi-agent systems.